What Are the Key Uses of 3,4-Difluoro-2-methoxyphenylboronic Acid?

Author: Jesse

Oct. 27, 2026

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Tags: Chemicals

3,4-Difluoro-2-methoxyphenylboronic acid is a compound that has garnered significant attention in the field of medicinal chemistry. This boronic acid derivative has various applications, notably in drug discovery and synthesis, making it an important subject of study among researchers and professionals in the pharmaceutical industry.

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Overview of 3,4-Difluoro-2-methoxyphenylboronic Acid

The CAS number for this compound is 905583-06-4. It belongs to a class of chemicals known as boronic acids, which are characterized by the presence of a boron atom connected to a hydroxyl group and organic groups. The unique structure of 3,4-difluoro-2-methoxyphenylboronic acid endows it with special properties that make it valuable in various chemical applications.

Key Chemical Properties

Understanding the chemical properties of 3,4-difluoro-2-methoxyphenylboronic acid is essential for its application:

  • **Molecular Formula**: C9H9B F2 O3
  • **Molecular Weight**: 205.97 g/mol
  • **Melting Point**: Approximately 150-155°C
  • **Solubility**: Soluble in organic solvents like ethanol and dimethyl sulfoxide (DMSO)

Applications in Pharmaceutical Industry

This compound is widely used as an intermediate in the synthesis of pharmaceuticals. Its ability to form reversible covalent bonds with biological molecules has made it particularly useful in drug design. Pharmaceutical intermediates manufacturers often rely on 3,4-difluoro-2-methoxyphenylboronic acid for the development of:

1. Anticancer Agents

Research indicates that boronic acids can inhibit proteasomes, which play a critical role in cancer cell survival. Studies suggest that derivatives like 3,4-difluoro-2-methoxyphenylboronic acid can impact tumor growth and progression.

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2. Antiviral Drugs

In the realm of antiviral drug development, this compound has been used as a key intermediate in synthesizing drugs that target viral proteases. Recent publications highlight its effectiveness in studies aimed at combating viruses like HIV and hepatitis C.

Role in Chemical Reactions

3,4-Difluoro-2-methoxyphenylboronic acid can also participate in various chemical reactions, including Suzuki coupling. This reaction helps chemists create biaryl compounds that are fundamental in organic synthesis. The versatility of this compound allows for a range of modifications, pivotal in materials science and organic electronics.

Market and Demand

According to a report by MarketsandMarkets, the global demand for boronic acids, including 3,4-difluoro-2-methoxyphenylboronic acid, is projected to experience consistent growth, driven by advancements in pharmaceuticals and innovative chemical applications. The expanding market for pharmaceutical intermediates underscores the importance of chemicals like this one.

Sourcing and Production

For manufacturers, sourcing high-quality raw materials is paramount. Pharmaceutical intermediates manufacturers play a critical role in producing 3,4-difluoro-2-methoxyphenylboronic acid in a cost-effective and environmentally friendly manner. Companies focus on ensuring purity and optimizing production processes to meet stringent regulatory requirements.

Conclusion

In summary, 3,4-difluoro-2-methoxyphenylboronic acid (CAS 905583-06-4) serves a pivotal role in the pharmaceutical landscape. Its applications span from drug development to advanced chemical syntheses, making it a key player in the arsenal of pharmaceutical intermediates manufacturers. As the demand continues to grow, so does the importance of rigorous research to unlock its full potential in pharmaceutical applications.

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